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Substitution of a mutant α2a-adrenergic receptor via “hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing …

PP Lakhlani, LB MacMillan, TZ Guo… - Proceedings of the …, 1997 - National Acad Sciences

… B6,129 male mice, ≈3 months old, were placed on an enclosed hot-plate (IITC Inc.); the
temperature of the plate was ramped at 6°C/min from 43°C to 52°C. When a mouse licked a hind
paw, the mouse was removed from the hot plate ａnd the temperature recorded …

  被引用次数371 相关文章 所有 11 个版本

Hot plate versus tail flickevaluation of acute tolerance to continuous morphine infusion in the rat model

L Langerman, MI Zakowski, B Piskoun… - … of pharmacological and …, 1995 - Elsevier

… The plate was adjusted to maintain a constant temperature of 52.5 + 0.2"C (Hot
Plate Model D, IITC INC., Woodlａnd Hills, CA). The animal was placed on the heated
surface until it licked hind paws or jumped (Carter, 1991) …

  被引用次数97 相关文章 所有 5 个版本

Neuroanatomical sites of action of neurotensin

PW Kalivas, CB Nemeroff… - Annals of the New York …, 1982 - Wiley Online Library

… Behavioral testing was begun one week after surgery. A hot plate (IITC, Inc., Model
35-D) was used to assess nociceptive threshold and was maintained at 55.0 -t 0.5"C.
The latency for the animal to lick its hind or forepaw or jump off the …

  被引用次数42 相关文章 所有 7 个版本

The behavioural effects of intrathecal galanin on tests of thermal and mechanical nociception in the rat

Z Wiesenfeld‐Hallin, XJ XU, JX HAO… - Acta physiologica …, 1993 - Wiley Online Library

… Only rats showing bilateral motor blockade were included in the study. The response of the rats
to noxious thermal stimuli was assessed with a hot plate (IITC, Woodlａnd Hills, CA, USA)
maintained at 54k0.2 "C. The paw withdrawal response to noxious mechanical stimuli …

  被引用次数52 相关文章 所有 4 个版本

Antinociceptive effects in mice after intrathecal injection of 5′-N-ethylcarboxamide adenosine

C Post - Neuroscience letters, 1984 - Elsevier

… The tail-flick test was performed with an IITC Model 33 Analgesiameter, and an IITC Model
35-D Analgesiameter for the hot-plate test. In the tail-flick test, the intensity of the light beam was
adjusted to achieve a reaction latency of 3-4 s before the drug was administered …

  被引用次数98 相关文章 所有 4 个版本

Intra-paragigantocellularis lateralis injection of orexin-A has an antinociceptive effect on hot plate ａnd formalin tests in rat

E Erami, H Azhdari-Zarmehri, E Ghasemi-Dashkhasan… - Brain research, 2012 - Elsevier

… minor modifications. In these experiments, the hot-plate (Analgesia meter IITC, Life
Science, USA) apparatus was maintained at 52±0.1 °C. The animals, presenting
training latencies higher than 30 s, were excluded. Animals …

  被引用次数45 相关文章 所有 8 个版本

Antagonism of nitrous oxide antinociception in the rat hot plate test by site-specific mu and epsilon opioid receptor blockade.

BL Hodges, MJ Gagnon, TR Gillespie… - … of Pharmacology and …, 1994 - ASPET

… After a 5-mm exposure period, the animal was quickly removed from the box and dropped onto
a hot plate analgesiometer (IITC, Wood- lａnd Hills, CA) with a Plexiglas enclosure (30 cm long
x 30 cm wide x 45 cm high) through which flowed the same concentration of N2O in 02 …

  被引用次数37 相关文章 所有 10 个版本

Hyperalgesia in mice lacking the Kv1. 1 potassium channel gene

JD Clark, BL Tempel - Neuroscience letters, 1998 - Elsevier

… hot plate assay was done as described by O'Callaghan and Holtzman [10]with equipment from
IITC … Taken together, the paw flick and hot plate data indicate that the effects of morphine are … of
focused light, Kv1.1 null mutants have shorter latencies, (2) using a hotplate assay in …

  被引用次数52 相关文章 所有 4 个版本

Evaluation of the antinociceptive activity and acute oral toxicity of standardized ethanolic extract of the rhizome of Curcuma xanthorrhiza Roxb

S Devaraj, AS Esfahani, S Ismail, S Ramanathan… - Molecules, 2010 -

… [11] with slight modifications. The hot plate test was assessed by the Incremental Hot plate (IITC
Life Sciences). The hot plate temperature was maintained at 55 ± 1 ºC. Prior to treatment, only
rats that showed response within 18 sec were selected for this study …

  被引用次数43 相关文章 所有 15 个版本 

Intrathecal γ-aminobutyric acidB (GABAB) receptor antagonist CGP 35348 induces hypersensitivity to mechanical stimuli in the rat

JX Hao, XJ Xu, Z Wiesenfeld-Hallin - Neuroscience letters, 1994 - Elsevier

… and was averaged. The responses to noxious heat was tested by placing the rats
on a hot plate (IITC, Woodlａnd Hills, CA, USA) maintained at 54 + 0.2°C and the
latency to licking a hindpaw was determined. All rats used in …

  被引用次数68 相关文章 所有 5 个版本