三合一痛觉测痛系统包含Electronic von Frey,Randall Selitto,Plethysmometer三套电子痛觉测痛仪用三种方法完成对大鼠小鼠等动物的痛觉测量欢迎。

• Electronic von Frey Anesthesiometer 电子von Frey测痛仪

• Randall Selitto test Paw Pressure Test Meter 鼠爪压力测量仪

• Plethysmometer, Paw Volume Meter or Paw Edema Meter鼠爪肿胀测量仪

型号2390型+2500型+520MR型

电子触觉阈疼痛阈测量仪机械痛阈测量仪Von Frey系统简单易用。用来替代传统的Von Frey Hairs纤毛机械刺激针（Von Frey Hairs）.不仅可以Von Frey test测试机械痛阈或触觉阈测量还可以测试疼痛阈值。它使研究者可以自动记录机械痛阈和触觉阈测量。操作简单精确设计紧凑。

电子Von Frey测痛仪的主要特点

Ø 适用MRI探针

Ø 单体内可插入三个探针

Ø LCD 显示屏 (Floating or last max. & minimum) 

Ø 硬枪头能达 800 Gr. 

Ø “Supertips™" 从15 到65Gr. 

Ø 适用1K探针

Ø 电子微处理器0.1Gr插入式探针

Ø 可选的模拟输出线

Ø 吸头可根据情况定制

Ø 具有测量、存储和显示功能免除了手算的繁琐。

Ø 可以预设和选择限额能精确到1g当到预设的限额时警示灯会通知使用人员。

Ø 实验简便选择合适的原件放在探针上插进实验对象根据实验对象的反应仪器就能快速的显示出结果并储存。

Ø 作为核心原件的内置传感器固定在元件上并和电子系统相连以便记录数据。所有的电子测痛仪已在出厂前校准完毕不再需要购买任何的校准设备。

鼠爪压力测痛仪 Randall&Selitto测试通过逐步提高作用于动物爪子上的机械压力逼近动物的疼痛阈限测量并记录动物产生逃避反应时的瞬间压力以测定动物机械钝痛的痛觉阈限。

与热痛不同鼠爪压力疼痛测痛仪用于机械压痛和钝痛的痛觉测量常用于辨别左右爪不同的痛觉反应多涉及脊髓神经过程人工辨别动物缩腿反应并用踏板控制马达的起止。

鼠爪压力疼痛测试仪的主要特点 

Ø 适用于大鼠和小鼠

Ø 精确度为0.1克压力400克

Ø 数字显示功能

Ø 配置脚踏控制器

Ø RS-232输出

鼠爪体积测量仪用来衡量消炎药的有效性。使用时讲大鼠、小鼠的爪子浸入含有特殊细胞的水中由于浸泡水的压力发生了变化。压力的变化会被校准并显示在特殊的电子监视器上。这种检测形式可以消除由于重复浸入发生导电性的改变而产生的改变这种情况在类似的其他仪器上发现过。测试结果直接显示在LCD上（大鼠精确到0.01毫升、小鼠精确到0.001毫升）。无论是用电池还是用9V或12V的适配器该设备表现稳定操作安全。

鼠爪肿胀测定仪的主要特点 

Ø 无需润湿液可消除由于重复浸入发生导电性的改变而产生的体积误差 

Ø 配备90°角的全透明亚克力操作支架可进行清晰方便

Ø 维护方便不需要特殊的护理液

Ø 数据准确不需要每次使用校准每年仅需校正一次

Ø 具有内置电源实现停电不间断操作

Ø 带LCD显示器读书方便

Ø 体积精确度0.01ml（大鼠）0.001ml（小鼠）

Order any one of the test systems complete and the only additional item(s) needed are the individual modules to perform each test.

Electronics has up to three inputs allowing users to perform three very different tests with one electronic system when studies call for doing so.

All data is stored and displayed in the electronics supplied.

Part# 2650 Stａnd and sling sold separately

Example:

Order any one of the 2390 Series Electronic von Frey systems; add on either or both the Digital Paw Pressure Applicator only and/or the glass stａnd setup only and you have a system that is complete for all three individual tests.

A wonderful addition to any laboratory facility studying analgesic compounds in research.

Stａnd and animal sling for Randall Selitto test sold separately.

部分参考文献

[HTML] An electronic pressure-meter nociception paw test for mice

TM Cunha, WA Verri Jr, GG Vivancos… - Brazilian Journal of …, 2004 - SciELO Brasil

... an inflammatory process and sensitized the paws of mice with different doses of carrageenin
ａnd prostaglandin E 2 (PGE 2 ... consisted of a hand-held force transducer fitted with a 0.5 mm
2 polypropylene tip (electronic von Frey anesthesiometer, IITC Inc., Life ...

[HTML] Pharmacological characterisation of a rat model of incisional pain

GT Whiteside, J Harrison, J Boulet… - British journal of …, 2004 - Wiley Online Library

... Pharma, Neuropharmacology, 6 Cedar Brook Drive, Cranbury, NJ 08512, USA E-mailgarth ... Issue
published online2 FEB 2009; Article first published online2 FEB 2009; ... previously described
in this modeltactile allodynia using an automated electronic von Frey (IITC, CA, USA ...

Pharmacological characterization of the chronic constriction injury model of neuropathic pain

J De Vry, E Kuhl, P Franken-Kunkel, G Eckel - European journal of …, 2004 - Elsevier

... 4 December 2003 Revised 1 March 2004 Accepted 25 March 2004 Available online 10 May
2004. Abstract. ... Mechanical allodynia was measured by means of a pressure transducer (electronic
von Frey Anaesthesiometer, IITC-Life Science Instruments, Woodlａnd Hills, CA). ...

Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats

EJ Rahn, AM Zvonok, GA Thakur, AD Khanolkar… - … of Pharmacology and …, 2008 - ASPET

... E-mailahohmann{at}uga.edu. Next Section. Abstract. ... Mechanical withdrawal thresholds were
assessed using a digital electronic von Frey anesthesiometer (IITC model Alemo 2290-4; IITC
Life Sciences Inc., Woodlａnd Hills, CA) equipped with a rigid tip. ...

Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, …

KJ Valenzano, L Tafesse, G Lee, JE Harrison… - …, 2005 - Elsevier

... 2004 Revised 26 November 2004 Accepted 10 December 2004 Available online 19 February ...
The marble-burying behavior model of anxiety (Njung'e ａnd Handley, 1990 ... noxious tactile stimulus
(VWT) were determined using an automated electronic von Frey apparatus (IITC ...

Taurine replacement attenuates hyperalgesia and abnormal calcium signaling in sensory neurons of STZ-D rats

F Li, IG Obrosova, O Abatan, D Tian… - American Journal of …, 2005 - Am Physiological Soc

... Digital sensory NCV (SNCV) was recorded in the digital nerve to the second toe by stimulating
with a square ... by quantifying the withdrawal threshold of the hindpaw in response to mechanical
stimulation using a von Frey anesthesiometer (model 2290C; IITC Life Science ...

Activation of presynaptic NMDA receptors coupled to NaV1. 8-resistant sodium channel C-fibers causes retrograde mechanical nociceptor sensitization

CA Parada, GG Vivancos, CH Tambeli… - Proceedings of the …, 2003 - National Acad Sciences

... Intrathecal administration of prostaglandin E 2 (PGE 2 ), glutamate, and NMDA causes a bilateral
long-lasting mechanical paw hypernociception ... reflex with a hand-held force transducer adapted
with a 0.5-mm 2 polypropylene tip (electronic von Frey hair; IITC Life Science ...

The use of an electronic von Frey device for evaluation of sensory threshold in neurologically normal dogs and those with acute spinal cord injury

SA Moore, BF Hettlich, A Waln - The Veterinary Journal, 2013 - Elsevier

... Accepted 3 November 2012 Available online 13 December 2012. Abstract. The ...
examination. von Frey device. The electronic von Frey device (IITC Life Science)
consisted of a load cell, handle, recording device and tip (Fig. 1 ...

Reproducibility of electronic von frey and von frey monofilaments testing

B Tena, B Escobar, MJ Arguis, C Cantero… - The Clinical journal …, 2012 -

... ReprintsBeatriz Tena, MD, Hospital Clinic, c/Villarroel 170, 08036 Barcelona, Spain (e-mail:
btena@clinic.ub.es ... Pain threshold was subsequently determined using a pressure algometer,
the Electronic von Frey (Electronic Von Frey Anesthesiometer IITC). ...

TrkA and PKC-epsilon in thermal burn–induced mechanical hyperalgesia in the rat

GJ Summer, KA Puntillo, C Miaskowski, OA Dina… - The Journal of …, 2006 - Elsevier

... Received 5 December 2005 Revised 12 April 2006 Accepted 12 April 2006 Available online
6 December ... threshold in animals that underwent a plantar surface burn was assessed using an
electronic von Frey (EvF) model 1601CE anesthesiometer (IITC Life Science ...

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